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Prostate cancer is a kind of cancer occurring in the prostate gland. With the development of research in recent years, prostate specific membrane antigen (PSMA) has become a new marker for the diagnosis and treatment of prostate cancer due to its high expression in most prostate cancer lesions. This makes it a promising diagnostic target (imaging via positron emission tomography [PET] scans) and a therapeutic target for radiation ligand therapy.
1 、NOTA-PSMA
Name NOTA-PSMA
Purity 98%
Sequence (Single Letter Abbreviation)
Sequence (Three Letter Abbreviation)
Basic Description
Molecular Weight 941.05
Chemical Formula C45H64N8O14
Storage Conditions Store at -20°C. Keep tightly closed. Store in a cool dry place.
Code 04010027777
CAS
REFERENCES
Molecular Graph
2 、PSMA
Name PSMA
Purity 98%
Sequence (Single Letter Abbreviation) E-urea-K
Sequence (Three Letter Abbreviation) Glu-rea-Lys
Basic Description
Molecular Weight 319.31
Chemical Formula C12H21N3O7
Storage Conditions Store at -20°C. Keep tightly closed. Store in a cool dry place.
Code 04010059069
CAS 1025796-69-3
REFERENCES
Molecular Graph
3 、PSMA-617 Linker
Name PSMA-617 Linker
Purity 95%
Sequence (Single Letter Abbreviation)
Sequence (Three Letter Abbreviation)
Basic Description Vipivotide tetraxetan Linker (PSMA-617 Linker) is a potent non-degradable peptide Linker for the synthesis of Vipivotide tetraxetan (PSMA-617). Vipivotide tetraxetan (PSMA-617) is a ligand for the synthesis of 177Lu-PSMA-617, a radioactive molecule used to study prostate cancer.
Molecular Weight 655.74
Chemical Formula C33H45N5O9
Storage Conditions Store at -20°C. Keep tightly closed. Store in a cool dry place.
Code
CAS 1703768-74-4
REFERENCES Benešová M, et al. Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile. Mol Pharm. 2018 Mar 5;15(3):934-946.
Molecular Graph
4 、PSMA-617
Name PSMA-617
Purity 98%
Sequence (Single Letter Abbreviation)
Sequence (Three Letter Abbreviation)
Basic Description PSMA-617 is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a Ki of 0.37 nM.
Molecular Weight 1042.14
Chemical Formula C49H71N9O16
Storage Conditions Store at -20°C. Keep tightly closed. Store in a cool dry place.
Code 04010047319
CAS 1702967-37-0
IN VITRO PSMA-617 demonstrates high radiolytic stability for at least 72 h. A high inhibition potency (equilibrium dissociation constant Ki=2.34±2.94 nM on LNCaP; Ki=0.37±0.21 nM enzymatically determined) and highly efficient internalization into LNCaP cells are demonstrated[1].
IN VIVO Organ distribution with 68Ga-labeled PSMA-617 after 1 h (n=3) reveals a high specific uptake in LNCaP tumors and in the kidneys. The high uptake in the kidneys is nearly completely blocked by coinjection of 2 mg o with the exception of the spleen. Tumor-to-background ratios are 7.8 (tumor to blood) and 17.1 (tumor to muscle) at 1 h after injection. As compared with the 68Ga-labeled version, the organ istribution with 177Lu-labeled PSMA-617 (n=3) show a similar uptake in the LNCaP tumors and in the kidneys. The liver uptake is found to be statistically different. Tumor-to-background ratios determined 1 h after injection show slightly higher values (tumor to blood, 22.1;tumor to muscle, 25.6) than previous organ distribution with 68Ga-labeled PSMA-617[1].
REFERENCES 1702967-37-0
Molecular Graph
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